Endocrine Abstracts

A 37-years-old man was referred to rheumatology with a 3 month history of widespread joint pains, worse on rising in the mornings with early morning stiffness lasting about 15 min. Hands were affected first followed by knees and hips. On further questioning, he also complained of generalised fatigue, loss of libido and thinning of the hair on his chest, as well as 15 kg weight loss over 6 months. He recalled a febrile illness with headache prior to the onset of his symptoms, b...

Adipogenesis is induced when intracellular cAMP increases and follows cell cycle arrest. During preadipocyte differentiation expression of the TSHR, which signals via cAMP and the inositol phosphate cascade, is upregulated. To investigate the role of TSHR activation in adipogenesis, we have developed an in vitro model in which constitutively active TSHR mutants (L629F, M453T) are introduced by retroviral vectors (RV).We aimed to compare the effect...

Introduction: The Autoimmune Polyendocrinopathy Syndromes (APS) comprise 4 clinical subtypes (1–4), APS type 1 is an autosomal recessive disorder caused by mutations in the AIRE (Autoimmune Regulator) gene. It should include at least 2 of the following 3 major criteria: chronic mucocutaneous candidiasis (CMC), hypoparathyroidism (HPT) and adrenal insufficiency (AI) although 50% of patients develop all 3 features, usually before the age of 20 years. In addition, there are ...

Objectives: To find out the proportion of patients with morbid obesity who may have co-existing eating disorders, using EAT-26 (Eating Attitude Test) Questionnaire.Method: All patients who attended the specialist morbid obesity clinic, between January 2005 and December 2007, at a university hospital were included in the study. EAT -26 questionnaires were given to the patients at the time of their referral. The specialist dietician took responsibility for...